What is NAC?
NAC is an acronym for N-acetyl-L-cysteine (a.k.a. n-acetylcysteine, n acetyl cysteine, n-acetyl-cysteine). Regardless of how you spell it, NAC is the supplemental form of the amino acid L-cysteine, with increased bioavailability. Outside of supplements, NAC can be found naturally in foods like onion, garlic, broccoli, and lean meats.
What are NAC’s benefits?
Cysteine is a building block for powerful antioxidants. It plays an important role in detoxification processes and liver function [2,3]. NAC can support addiction recovery [4-6]. It contributes to mental health through neurotransmitter regulation . It is also taken as a respiratory support supplement.
NAC is known as a respiratory support supplement for a number of reasons. First, NAC supports increased glutathione levels in the respiratory system . Glutathione is the body’s master antioxidant. It is super-efficient at neutralising oxidants and preventing cellular damage.
Second, NAC is a mucolytic nutrient. It helps to loosen and clear excess mucus from the lungs and bronchial tubes .
Third, last but not least, NAC can help to reduce excessive inflammation in bronchial tubes and lung tissue at times of infection or in disease states . This fact is especially relevant in 2021, as maintenance of respiratory health has literally become an issue of life or death.
NAC and Immune Health
After more than a year of viral threat, lockdowns, and quarantines, immune-boosting supplements like NAC have gained serious popularity.
Data from a 2020 study published in Therapeutics and Clinical Risk Management indicate that the antioxidant, anti-inflammatory, and immune-boosting properties of NAC may prove beneficial in the body’s defense against acute respiratory illness .
The journal Future Microbiology published a review that named NAC as an immune support supplement for healthcare workers, or those who were likely to face repeated exposure to a viral threat .
- National Institutes of Health. Dietary Supplements in the Time of COVID-19. Fact Sheet for Health Professionals. 2021
- Bauer SR, Kapoor A, Rath M, Thomas SA. What is the role of supplementation with ascorbic acid, zinc, vitamin D, or N-acetylcysteine for prevention or treatment of COVID-19? Cleve Clin J Med 2020.
- Mokhtari, Vida, et al. “A review on various uses of N-acetyl cysteine.” Cell Journal (Yakhteh) 19.1 (2017): 11.
- Grant, Jon E., Brian L. Odlaug, and Suck Won Kim. “N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study.” Archives of general psychiatry 66.7 (2009): 756-763
- Gray, Kevin M., et al. “N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study.” The American journal on addictions/American Academy of Psychiatrists in Alcoholism and Addictions 19.2 (2010): 187.
- McClure, Erin A., et al. “Potential role of N-acetylcysteine in the management of substance use disorders.” CNS drugs 28.2 (2014): 95-106.
- Shi Z, Puyo CA. N-acetylcysteine to combat COVID-19: An evidence review. Therapeutics and Clinical Risk Management. 2020;16:1047-1055.
- Jorge-Aarón RM, Rosa-Ester MP. N-acetylcysteine as a potential treatment for COVID-19. Future Microbiology. 2020;15:959-962.
- U.S. Food and Drug Administration. National Drug Code Directory. 2021.
- U.S. Food and Drug Administration. Warning Letter, Happy Hour Vitamins, MARCS-CMS 593770 2020.
- National Institutes of Health. Dietary Supplement Label Database. 2021.
What Is It?
Quercetin belongs to a class of water-soluble plant pigments called
bioflavonoids that cannot be produced in the human body. It is also
considered a phytoestrogen.‡
Uses For Quercetin
Immune Support: Quercetin supports healthy mast cell function.
An in vitro study performed on neutrophils reported that quercetin
mediated beta-glucuronidase and lysozyme release, and significantly
moderated arachidonic acid release from cell membranes.‡
Antioxidant Support: Quercetin promotes cardiovascular health by
protecting lipids from oxidation and supporting the health of capillaries
by enhancing their strength and integrity. Studies suggest that quercetin
may also promote healthy vision by mediating sorbitol production.‡
Cellular Support: An animal study indicated that quercetin
supported prostate cell health by moderating receptor function at
the transcription level. Additionally, in vitro studies have reported
that this powerful flavonoid may be supportive of colon and breast
What Is The Source?
Pure Encapsulations Quercetin is derived from Fava d’anta tree
(Dimorphandra mollis) pods.
Pure Encapsulations® recommends 2 capsules, 1–2 times daily,
Are There Any Potential Side Effects Or
At this time, there are no known side effects or precautions. If
pregnant or lactating, consult your physician before taking this
Are There Any Potential Drug Interactions?
Quercetin may react with calcium channel blockers, estradiol,
and immune suppressive drugs. Consult your physician for more
- Supports immune system function‡
- Promotes reproductive health‡
- Made with high-quality vegan ingredients backed by verifiable science
Zinc is designed to support the body’s natural defense system as well as enhance digestion and metabolism of important vitamins, minerals, carbohydrates and other essential nutrients. Zinc is also essential for normal fetal and reproductive development.‡